Effects of magnesium and zinc deficiencies on growth and protein synthesis in skeletal muscle and the heart

The effects of magnesium or zinc deficiency on growth, tissue contents of Mg or Zn and protein synthesis have been compared in 4–13-week-old rats. When maintained on Mg-deficient fodder (1.6 mmol/kg) or Zn-deficient fodder (27 μmol/kg) rats showed a reduced weight gain, whereas repletion caused incr...

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Veröffentlicht in:	British journal of nutrition 1991-11, Vol.66 (3), p.493-504
Hauptverfasser:	Dørup, Inge, Clausen, Torben
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Female Growth Interaction involving Inorganic Nutrients Leucine - metabolism Magnesium deficiency Magnesium Deficiency - metabolism Medical sciences Metabolic diseases Muscle Proteins - biosynthesis Myocardium - metabolism Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Phenylalanine - metabolism Potassium - metabolism Protein synthesis Rat Rats Rats, Inbred Strains Time Factors Weight Gain - physiology Zinc - deficiency
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Zusammenfassung:	The effects of magnesium or zinc deficiency on growth, tissue contents of Mg or Zn and protein synthesis have been compared in 4–13-week-old rats. When maintained on Mg-deficient fodder (1.6 mmol/kg) or Zn-deficient fodder (27 μmol/kg) rats showed a reduced weight gain, whereas repletion caused increased growth rates. Pair-feeding experiments showed that this could not be attributed to reduced energy intake only. In rats maintained on Mg-deficient fodder for 14 d [3H]leucine incorporation into skeletal muscle and the heart was reduced by 24–38% compared with pair-fed controls (P
ISSN:	0007-1145 1475-2662
DOI:	10.1079/BJN19910050