Hyaluronan and wound healing: a new perspective

Hyaluronan has long been associated with the remodelling extracellular matrix. Such remodelling occurs in development, growth and wound healing. This role has been thought to be related to the physical structure and chemical composition of the pure glycosaminoglycan chain. We question this propositi...

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Veröffentlicht in:	British journal of plastic surgery 1991-11, Vol.44 (8), p.579-584
Hauptverfasser:	Burd, D. Andrew R., Ritz, Morris, Regauer, Sigrid, Longaker, Michael T., Siebert, John W., Garg, Hari
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Animals Biological and medical sciences Cells, Cultured Epithelium - drug effects Fibroblasts - drug effects Humans Hyaluronic Acid - analysis Hyaluronic Acid - pharmacology In Vitro Techniques Medical sciences Mitosis - drug effects Sheep Skin - injuries Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Wound Healing - drug effects
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Zusammenfassung:	Hyaluronan has long been associated with the remodelling extracellular matrix. Such remodelling occurs in development, growth and wound healing. This role has been thought to be related to the physical structure and chemical composition of the pure glycosaminoglycan chain. We question this proposition and present evidence which suggests that proteins associated with hyaluronan may be more critical determinants of tissue remodelling.
ISSN:	0007-1226 1465-3087
DOI:	10.1016/0007-1226(91)90093-Y