Interaction of a synthetic peptide of the interferon α-2 C-terminal part with human blood leukocytes: Binding to peripheral blood mononuclear cells

A biologically active synthetic peptide, 2438, representing the 124–138 amino acid sequence of the human interferon α-2 (IFN α-2) molecule, which is known to possess IFN-like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different K fd values, f...

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Veröffentlicht in:	FEBS letters 1991-12, Vol.295 (1), p.70-72
Hauptverfasser:	Danilkovitch, A.V., Kharitonenkov, A.I., Freze, K.V., Shevalier, A.F., Kolosova, O.V., Bulargina, T.V., Kirkin, A.F., Gusev, M.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity B-Lymphocytes - metabolism Binding Sites Binding, Competitive Biological and medical sciences Cell Membrane - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Human Humans IFN α-2 Immunobiology In Vitro Techniques Interferon-alpha - metabolism Kinetics Leukocytes, Mononuclear - metabolism Lymphocyte Microbiology Miscellaneous Peptides - chemical synthesis Peptides - metabolism Regulatory factors and their cellular receptors Specific binding Synthetic peptide T-Lymphocytes - metabolism
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Zusammenfassung:	A biologically active synthetic peptide, 2438, representing the 124–138 amino acid sequence of the human interferon α-2 (IFN α-2) molecule, which is known to possess IFN-like antiproliferative activity, specifically binds to human blood leukocytes. Scatchard plots reveal two different K fd values, for the ‘low’ and ‘high’ affinity binding. The interaction of the 125I-labelled peptide 2438 with the cells is not impaired by human IFN α-2 or cholera toxin.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(91)81387-N