Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes

Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes

Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY,+8,+8,−14,+der(14)t(1;14)(q11;p11),i(17q) and 51,XY,+5,+6,+8,+8,−14+20,+der (14)t(1;14)(q11;p11),i(17q),+dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification...

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Veröffentlicht in:Cancer genetics and cytogenetics 1991-12, Vol.57 (2), p.181-186
Hauptverfasser: Sawyer, Jeffrey R., Swanson, Charles M., Roloson, Gary J., Longee, Darryl C., Boop, Frederick A., Chadduck, William M.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blotting, Southern
Cerebellar Neoplasms - pathology
Child, Preschool
chromosome 17
Chromosome Aberrations - pathology
Chromosome Disorders
Chromosomes, Human, Pair 17
double minute chromosomes
Genes, myc
Humans
Karyotyping
Male
Medical sciences
Medulloblastoma - pathology
Neurology
Time Factors
Tumor Cells, Cultured
Tumors of the nervous system. Phacomatoses
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Zusammenfassung:Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY,+8,+8,−14,+der(14)t(1;14)(q11;p11),i(17q) and 51,XY,+5,+6,+8,+8,−14+20,+der (14)t(1;14)(q11;p11),i(17q),+dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(91)90150-S