A selenide linker for "traceless" solid-phase organic synthesis

A selenide linker for "traceless" solid-phase organic synthesis

4‐Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid‐phase resins. The polymer‐bound selenide anion is then generated, and functions as...

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Veröffentlicht in:Biotechnology and bioengineering 2000, Vol.71 (2), p.104-106
Hauptverfasser: Li, Zhengong, Kulkarni, Bheemashankar A., Ganesan, A.
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Chemistry
Exact sciences and technology
Organic Chemicals - chemical synthesis
Organic chemistry
Preparations and properties
selenides
Selenium Compounds - chemistry
solid-phase synthesis
traceless linkers
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Zusammenfassung:4‐Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid‐phase resins. The polymer‐bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides. © 2001 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 71:104–106, 2000/2001.
ISSN:0006-3592
1097-0290
DOI:10.1002/1097-0290(2000)71:2<104::AID-BIT1000>3.0.CO;2-7