Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion
Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D 2 agonist, quinpirole, into the nucleus accumbens reduced significantly both explorato...
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| Veröffentlicht in: | Brain research bulletin 1991-11, Vol.27 (5), p.743-746 |
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| container_title | Brain research bulletin |
| container_volume | 27 |
| creator | Mogenson, Gordon J. Wu, Michael |
| description | Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D
2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms. |
| doi_str_mv | 10.1016/0361-9230(91)90057-Q |
| format | Article |
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2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms.</description><subject>Amphetamine - antagonists & inhibitors</subject><subject>Amphetamine - pharmacology</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Dopamine</subject><subject>Dopamine Agents - pharmacology</subject><subject>Ergolines - administration & dosage</subject><subject>Ergolines - pharmacology</subject><subject>Exploratory Behavior - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Locomotion</subject><subject>Male</subject><subject>Microinjections</subject><subject>Motor Activity - drug effects</subject><subject>Neurotransmission and behavior</subject><subject>Nucleus accumbens</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Quinpirole</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stereotaxic Techniques</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFEEQhhsxxDX6DxTmIGIOE_t7ui-CBI2BQFjUc9NbXUNaZqbH7p5g_r2z7BJv5vQe3qeKqoeQN4xeMMr0Ryo0ay0X9INl55ZS1bXbZ2TDTCda3snuOdk8Ii_Iy1J-UUq1UfqUnDJtpOJ2Q75vlzjNMacBm5qaeoeNB1jGHU6lyRgWwNLgn3lI2deUHxo_hcaP8x1WP8YJWxwixIqhGRKkMdWYplfkpPdDwdfHPCM_v375cfmtvbm9ur78fNOCErK2omNKcNuZnbbSYOBBoPWaKS2YBaO55EYGBI3KMAhCB2DCyJ3vjbBB9eKMvD_snXP6vWCpbowFcBj8hGkpruOqU5rpJ0GmGRWcyRWUBxByKiVj7-YcR58fHKNuL93tjbq9UWfX3Et323Xs7XH_shsx_Bs6WF77d8feF_BDn_0EsTxiinO7frZinw4YrtLuI2ZXIOIEGGJGqC6k-P87_gL9g525</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Mogenson, Gordon J.</creator><creator>Wu, Michael</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19911101</creationdate><title>Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion</title><author>Mogenson, Gordon J. ; Wu, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-371532978b6948ed2d3e9a6156319c8624284dec6e581cd36dc1384baf839d5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amphetamine - antagonists & inhibitors</topic><topic>Amphetamine - pharmacology</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Dopamine</topic><topic>Dopamine Agents - pharmacology</topic><topic>Ergolines - administration & dosage</topic><topic>Ergolines - pharmacology</topic><topic>Exploratory Behavior - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Locomotion</topic><topic>Male</topic><topic>Microinjections</topic><topic>Motor Activity - drug effects</topic><topic>Neurotransmission and behavior</topic><topic>Nucleus accumbens</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Quinpirole</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stereotaxic Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogenson, Gordon J.</creatorcontrib><creatorcontrib>Wu, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogenson, Gordon J.</au><au>Wu, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>27</volume><issue>5</issue><spage>743</spage><epage>746</epage><pages>743-746</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D
2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1684529</pmid><doi>10.1016/0361-9230(91)90057-Q</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1991-11, Vol.27 (5), p.743-746 |
| issn | 0361-9230 1873-2747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72575616 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amphetamine - antagonists & inhibitors Amphetamine - pharmacology Animals Behavioral psychophysiology Biological and medical sciences Dopamine Dopamine Agents - pharmacology Ergolines - administration & dosage Ergolines - pharmacology Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology Locomotion Male Microinjections Motor Activity - drug effects Neurotransmission and behavior Nucleus accumbens Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quinpirole Rats Rats, Inbred Strains Stereotaxic Techniques |
| title | Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion |
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