Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion

Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D 2 agonist, quinpirole, into the nucleus accumbens reduced significantly both explorato...

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Veröffentlicht in:	Brain research bulletin 1991-11, Vol.27 (5), p.743-746
Hauptverfasser:	Mogenson, Gordon J., Wu, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - antagonists & inhibitors Amphetamine - pharmacology Animals Behavioral psychophysiology Biological and medical sciences Dopamine Dopamine Agents - pharmacology Ergolines - administration & dosage Ergolines - pharmacology Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology Locomotion Male Microinjections Motor Activity - drug effects Neurotransmission and behavior Nucleus accumbens Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quinpirole Rats Rats, Inbred Strains Stereotaxic Techniques
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Zusammenfassung:	Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D 2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/0361-9230(91)90057-Q