The value of an expert system in performing clinical drug trials

An expert system has been designed to assist the cardiologist in determining whether patients can be included in clinical trials. This system contains knowledge on inclusion and exclusion criteria for six drug trials, and has been validated in 100 randomly selected patients. In 97 cases, the expert...

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Veröffentlicht in:	Computers in biology and medicine 1991, Vol.21 (4), p.193-198
Hauptverfasser:	Dassen, Willem R.M., Mulleneers, Rob, Frank, Herman L.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina, Unstable - classification Biological and medical sciences Clinical Trials as Topic - methods Data Interpretation, Statistical Decision support Diseases of the osteoarticular system. Orthopedic treatment Drug trials Expert system Expert Systems Humans Medical sciences Myocardial Infarction - classification Observer Variation Pulmonary Embolism - classification Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tachycardia - classification User-Computer Interface
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Beschreibung
Zusammenfassung:	An expert system has been designed to assist the cardiologist in determining whether patients can be included in clinical trials. This system contains knowledge on inclusion and exclusion criteria for six drug trials, and has been validated in 100 randomly selected patients. In 97 cases, the expert system and the cardiologist made an identical classification; in the remaining three cases, the patient was incorrectly classified by the physician. The system will also optimize the order in which questions are asked in order to minimize the time required to decide on inclusion or exclusion.
ISSN:	0010-4825 1879-0534
DOI:	10.1016/0010-4825(91)90001-P