Comparison of Bone Mineral Density of the Phalanges, Lumbar Spine, Hip, and Forearm for Assessment of Osteoporosis in Postmenopausal Women

The objective of this study was to compare peripheral bone mineral density (BMD) of the phalanges with BMD of the lumbar spine, total hip, femoral neck, and forearm and to determine the clinical value of measuring a single peripheral site (phalanges) in identifying postmenopausal women with osteoporosis. BMD was measured by dual-energy X-ray absorptiometry using the accuDEXA® (ADXA-finger) (Schick, New York, NY) and the QDR-4500 (DXA—lumbar spine, hip, forearm) (Hologic, Waltham, MA). Correlation coefficients between ADXA and DXA of the lumbar spine, total hip, femoral neck, and one third radial site ranged from 0.53 to 0.73. The sensitivity of an ADXA T-score of –2.5 in identifying patients with a DXA T-score of ≤−2.5 at the femoral neck was 35%. An ADXA T-score cut point of –1.0 improved the sensitivity of ADXA in identifying patients with a femoral neck T-score of ≤−2.5 (85%), but the specificity declined from 88 to 49%. There was substantial discordance in the diagnosis of osteoporosis when a single site was measured, regardless of technique. Within the limitations of single-site measurements, BMD measured by ADXA has adequate sensitivity to identify women with low BMD at the femoral neck, if an appropriate T-score criterion is used.