Antioxidant properties of thiamine

Thiamine (10(-4)-10(-6)M) inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant effect of thiamine is probably related to su...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2000-09, Vol.130 (9), p.874-876
Hauptverfasser:	Lukienko, P I, Mel'nichenko, N G, Zverinskii, I V, Zabrodskaya, S V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Male Mice Microsomes, Liver - drug effects Thiamine - pharmacology Vitamin B
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Beschreibung
Zusammenfassung:	Thiamine (10(-4)-10(-6)M) inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant effect of thiamine is probably related to successive transfer of 2H(+)from the NH(2)group of the pyrimidine ring and H(+)from the thiazole ring (after its opening) to reactive substrates.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1015318413076