Cerivastatin modulates antiatherogenic properties of high-density lipoproteins in patients with coronary heart disease and hyperlipidemia

The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their choleste...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2000-10, Vol.130 (10), p.983-985
Hauptverfasser:	Ozerova, I N, Jeevan, D M, Serdyuk, A P, Paramonova, I V, Akhmedzhanov, N M, Metel'skaya, V A, Perova, N V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arteriosclerosis - prevention & control Cholesterol - blood Coronary Disease - blood Coronary Disease - drug therapy Double-Blind Method Humans Hyperlipidemias - blood Hyperlipidemias - drug therapy Lipoproteins, HDL - blood Lipoproteins, HDL - chemistry Lipoproteins, HDL - drug effects Male Middle Aged Phospholipids - blood Phospholipids - chemistry Pyridines - pharmacology
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Zusammenfassung:	The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor properties. This effect was most pronounced in the serum from patients with low content of high-density lipoprotein cholesterol. These data indicate that cerivastatin modulates antiatherogenic properties of high-density lipoproteins.
ISSN:	0007-4888
DOI:	10.1023/A:1002822109154