Quinolactacins A, B and C: Novel Quinolone Compounds from Penicillium sp. EPF-6: I. Taxonomy, Production, Isolation and Biological Properties

Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristi...

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Veröffentlicht in:	Journal of antibiotics 2000/11/25, Vol.53(11), pp.1247-1251
Hauptverfasser:	KAKINUMA, NORIHIRO, IWAI, HIROKI, TAKAHASHI, SENJI, HAMANO, KUNIKATSU, YANAGISAWA, TADASHI, NAGAI, KOJI, TANAKA, KOICHI, SUZUKI, KENICHI, KIRIKAE, FUMIKO, KIRIKAE, TERUO, NAKAGAWA, AKIRA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - classification Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Female Fermentation Fundamental and applied biological sciences. Psychology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Margaronia pyloalis Mice Mice, Inbred C3H Microbial Sensitivity Tests Microbiology Microscopy, Electron, Scanning Molecular Structure Penicillium Penicillium - chemistry Penicillium - ultrastructure quinolactacin A quinolactacin B quinolactacin C quinolones Quinolones - chemical synthesis Quinolones - classification Quinolones - isolation & purification Quinolones - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis
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Zusammenfassung:	Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against tumor necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.1247