Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines
We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated inter...
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| Veröffentlicht in: | Leprosy review 2000-12, Vol.71 Suppl, p.S176-S181, Article 176 |
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| container_end_page | S181 |
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| container_start_page | S176 |
| container_title | Leprosy review |
| container_volume | 71 Suppl |
| creator | Britton, W J Martin, E Kamath, A T Neupane, K D Roche, P W |
| description | We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice. |
| doi_str_mv | 10.5935/0305-7518.20000091 |
| format | Article |
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A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.</description><subject>Animals</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Leprosy - immunology</subject><subject>Leprosy - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Sensitivity and Specificity</subject><subject>Vaccines, Subunit - administration & dosage</subject><issn>0305-7518</issn><issn>2162-8807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAYRS0EoqXwAgwoE1uKf-LYHlFFoVKBBWbLdhxqlD9sB-jbk6gFJAa-5VvOvbo6AJwjOKeC0CtIIE0ZRXyO4XgCHYApRjlOOYfsEEx_gAk4CeEVQoKQIMdgghCGiDM-BQ-ruu6btvNtt9lW6tOFRL0o14SY3G9Nq5WJ1ru-TirbeWUT15TWRNc2yYeLmyT0um9cTN6VMa6x4RQclaoK9mz_Z-B5efO0uEvXj7erxfU6NViImArNLeE0J6IYJlFlKVMmy4xgDOa4zHNoNTJC49yUpBC54BoLpg1HBeWZwWQGLne9w_C33oYoaxeMrSrV2LYPkmGaCcHRAOIdaHwbgrel7Lyrld9KBOVoUY6S5ChJflscQhf79l7XtviN7LUNAP_TalxUo5bolav-6_4CbOl_SQ</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Britton, W J</creator><creator>Martin, E</creator><creator>Kamath, A T</creator><creator>Neupane, K D</creator><creator>Roche, P W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines</title><author>Britton, W J ; Martin, E ; Kamath, A T ; Neupane, K D ; Roche, P W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-9b8e385639d3115ae57ac44c977062f660eb1c9b26cf3d9698b297bc81d584c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Leprosy - immunology</topic><topic>Leprosy - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Sensitivity and Specificity</topic><topic>Vaccines, Subunit - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Britton, W J</creatorcontrib><creatorcontrib>Martin, E</creatorcontrib><creatorcontrib>Kamath, A T</creatorcontrib><creatorcontrib>Neupane, K D</creatorcontrib><creatorcontrib>Roche, P W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Leprosy review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Britton, W J</au><au>Martin, E</au><au>Kamath, A T</au><au>Neupane, K D</au><au>Roche, P W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines</atitle><jtitle>Leprosy review</jtitle><addtitle>Lepr Rev</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>71 Suppl</volume><spage>S176</spage><epage>S181</epage><pages>S176-S181</pages><artnum>176</artnum><issn>0305-7518</issn><eissn>2162-8807</eissn><abstract>We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. 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| ispartof | Leprosy review, 2000-12, Vol.71 Suppl, p.S176-S181, Article 176 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Bacterial Vaccines - administration & dosage Disease Models, Animal Leprosy - immunology Leprosy - prevention & control Mice Mice, Inbred Strains Sensitivity and Specificity Vaccines, Subunit - administration & dosage |
| title | Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines |
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