Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines

We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated inter...

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Veröffentlicht in:	Leprosy review 2000-12, Vol.71 Suppl, p.S176-S181, Article 176
Hauptverfasser:	Britton, W J, Martin, E, Kamath, A T, Neupane, K D, Roche, P W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Vaccines - administration & dosage Disease Models, Animal Leprosy - immunology Leprosy - prevention & control Mice Mice, Inbred Strains Sensitivity and Specificity Vaccines, Subunit - administration & dosage
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Zusammenfassung:	We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.
ISSN:	0305-7518 2162-8807
DOI:	10.5935/0305-7518.20000091