Modulation of recombinant T-type Ca2+ channels by hypoxia and glutathione

Modulation of recombinant T-type Ca2+ channels by hypoxia and glutathione

T-type Ca2+ channels are expressed in a wide variety of central and peripheral neurons and play an important role in neuronal firing and rhythmicity. Here we examined the effects of hypoxia on the recently cloned T-type Ca2+ channel alpha1G, alpha1H and alpha1I subunits, stably expressed in HEK 293...

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Veröffentlicht in:Pflügers Archiv 2000-12, Vol.441 (2-3), p.181-188
Hauptverfasser: Fearon, I M, Randall, A D, Perez-Reyes, E, Peers, C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium Channels, T-Type - drug effects
Calcium Channels, T-Type - genetics
Calcium Channels, T-Type - physiology
Cell Hypoxia - physiology
Cell Line
Electric Conductivity
Embryo, Mammalian
Gene Expression
Glutathione - pharmacology
Humans
Hypoxia
Kidney
Nickel - pharmacology
Oxidation-Reduction
Oxygen - administration & dosage
Rats
Recombinant Proteins - metabolism
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Zusammenfassung:T-type Ca2+ channels are expressed in a wide variety of central and peripheral neurons and play an important role in neuronal firing and rhythmicity. Here we examined the effects of hypoxia on the recently cloned T-type Ca2+ channel alpha1G, alpha1H and alpha1I subunits, stably expressed in HEK 293 cells. In cells expressing the human alpha1H or the rat alpha1I subunit, Ca2+ channel currents were inhibited reversibly by hypoxia (PO2
ISSN:0031-6768
1432-2013
DOI:10.1007/s004240000424