Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma

Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2000-04, Vol.129 (4), p.383-385
Hauptverfasser:	Amandzholov, B S, Sitdikova, S M, Lebedin, Y S, Chukanov, S V, Toptygin, A Y, Manzyuk, L V, Donenko, F V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen (tumor-associated) Antigenic determinants Antigens Antitumor activity CA-125 Antigen - immunology CA-125 Antigen - therapeutic use Female Humans Immunoglobulin G Immunoglobulin M Immunotherapy Life span Mice Mice, Inbred CBA mucin Mucins - immunology Mucins - therapeutic use Neoplasm Transplantation Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Titration Tumors
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Zusammenfassung:	Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was -0.4 for IgM and -0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/BF02439278