DNA ploidy determination with flow cytometry, Ki-67 index, and overexpression of p53 protein in 121 T1 superficial bladder carcinoma. Retrospective study. Correlation with classic variables

Observe the correlation between Ki-67 label index, p53 expression and flow cytometry-DNA ploidy with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary). 121 superficial bladder tumors T1. 10% Cut-off level for Ki-67 and p53. Aneuploidy is defined as a tumor with DNA i...

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Veröffentlicht in:	Actas urologicas españolas 2000-11, Vol.24 (10), p.785-795
Hauptverfasser:	Moyano Calvo, J L, de Miguel Rodríguez, M, Ortiz Gamiz, A, Poyato Galán, J M, Sánchez Sánchez, E, Blanco Palenciano, E, Arribas Rodríguez, J M, Galera Davidson, H, Castiñeiras Fernández, J
Format:	Artikel
Sprache:	spa
Schlagworte:	Aged Female Flow Cytometry Gene Expression Regulation, Neoplastic Humans Ki-67 Antigen - analysis Male Ploidies Retrospective Studies Tumor Suppressor Protein p53 - genetics Urinary Bladder Neoplasms - genetics
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Zusammenfassung:	Observe the correlation between Ki-67 label index, p53 expression and flow cytometry-DNA ploidy with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary). 121 superficial bladder tumors T1. 10% Cut-off level for Ki-67 and p53. Aneuploidy is defined as a tumor with DNA index different of 1 or more than 20% in G2-M phase. Statistical correlation with grade and lymphatic permeation. Ki-67 label index and p53 expression can distinguish between G1, G2 vs G3 and Lx, L0 vs. L1. The volume correlates with positivity to p53. Aneuploidy and positivity to Ki-67 and p53 increase with grade and lymphatic permeation.
ISSN:	0210-4806