Anti-Hepatitis B Virus Effects of Wogonin Isolated from Scutellaria baicalensis

Abstract By using an HBV-producing cell line (MS-G2) IN VITRO culture system, we found that wogonin isolated from SCUTELLARIA BAICALENSIS can suppress HBV surface antigen production (P < 0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that...

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Veröffentlicht in:	Planta medica 2000-12, Vol.66 (8), p.694-698
Hauptverfasser:	Huang, Ray-Ling, Chen, Chien-Chih, Huang, Huey-Lan, Chang, Chung-Gwo, Chen, Chieh-Fu, Chang, Chungming, Hsieh, Ming-Tsuen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Flavanones Flavonoids - isolation & purification Flavonoids - pharmacology General pharmacology Hepatitis B virus - drug effects Humans Lamiaceae - chemistry Medical sciences Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Tumor Cells, Cultured
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Zusammenfassung:	Abstract By using an HBV-producing cell line (MS-G2) IN VITRO culture system, we found that wogonin isolated from SCUTELLARIA BAICALENSIS can suppress HBV surface antigen production (P < 0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2000-9775