Linkage between the Hormone Binding Site and the Reactive Center Loop of Thyroxine Binding Globulin

Thyroxine binding globulin (TBG) is the major carrier of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in plasma. TBG is member of the serpin family of proteins although it has no proteinase inhibitory activity. In this study we show that TBG has properties typical of a metastable se...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2000-12, Vol.384 (1), p.31-36
Hauptverfasser:	Suda, Scott A., Gettins, Peter G.W., Patston, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilino Naphthalenesulfonates - metabolism Binding Sites fluorescence spectroscopy Hormones - metabolism Humans Models, Molecular Peptide Hydrolases - metabolism Protein Conformation protein stability proteolytic cleavage serpin thyroid hormones thyroxine binding globulin Thyroxine-Binding Proteins - chemistry Thyroxine-Binding Proteins - metabolism
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