Synthesis and theoretical study of 2-amino-2,3,3a, 4,5,6-hexahydro-1H-phenalene and its biological evaluation on central dopaminergic system

Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and 6 h of urine collection. We speculate that co...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2000-09, Vol.55 (9-10), p.575-582
Hauptverfasser:	ANGEL-GUIO, J. E, CHARRIS, J. E, CALDERA, J, MICHELENA DE BAEZ, E, ARRIETA, F, PEREZ, J, DUERTO DE PEREZ, Z, COMPAGNONE, R, ISRAEL, A, ORFILA, L, MIGLIORE DE ANGEL, B, LOPEZ, S. E, RODRIGUEZ, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Amines - pharmacology Animals Biological and medical sciences Diuresis - drug effects Dopamine Antagonists - chemical synthesis Dopamine Antagonists - chemistry Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Male Medical sciences Molecular Structure Natriuresis - drug effects Pharmacology. Drug treatments Phenalenes Polycyclic Compounds - chemical synthesis Polycyclic Compounds - chemistry Polycyclic Compounds - pharmacology Potassium - urine Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - antagonists & inhibitors Sodium - urine Urinary system
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Zusammenfassung:	Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and 6 h of urine collection. We speculate that compound 2 may be acting as a dopamine receptor antagonist.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(00)00081-1