Detailed study of the different taurine uptake systems of colon LoVo MDR and non-MDR cell lines

Detailed study of the different taurine uptake systems of colon LoVo MDR and non-MDR cell lines

In human, physiological taurine requirement is partly dependent on nutrition. Study of the human carcinoma LoVo cells shows the presence of a high and a low affinity taurine uptake. Besides them, a diffusion system has been found. A detailed analysis of the properties of the three systems is present...

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Veröffentlicht in:Amino acids 2000-01, Vol.19 (3-4), p.667-685
Hauptverfasser: Wersinger, C, Rebel, G, Lelong-Rebel, I H
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis
ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
Biological Transport
Cell Line
Colon
Colon - metabolism
Colon - pathology
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Glycoproteins
Humans
Nutrition
P-Glycoprotein
Taurine
Taurine - metabolism
Transfection
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Beschreibung
Zusammenfassung:In human, physiological taurine requirement is partly dependent on nutrition. Study of the human carcinoma LoVo cells shows the presence of a high and a low affinity taurine uptake. Besides them, a diffusion system has been found. A detailed analysis of the properties of the three systems is presented. A comparison of LoVo chemosensitive cells, and LoVo chemoresistant (MDR) cells which overexpress the multidrug transporter P-glycoprotein, shows that the only difference between the two cell types belong to the kinetic properties of the high and low affinity taurine uptake systems.
ISSN:0939-4451
1438-2199
DOI:10.1007/s007260070015