Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1: Taxonomy, Fermentation, Isolation and Biological Activities

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered...

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Veröffentlicht in:	Journal of antibiotics 2000/10/25, Vol.53(10), pp.1130-1136
Hauptverfasser:	NAKAE, KOICHI, YOSHIMOTO, YUYA, SAWA, TSUTOMU, HOMMA, YOSHIKO, HAMADA, MASA, TAKEUCH, TOMIO, IMOTO, MASAYA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic agents Applied microbiology Biological and medical sciences Cell Movement - drug effects Cell Survival - drug effects Chemotaxis - drug effects Chemotherapic agents DNA - biosynthesis Drug Screening Assays, Antitumor Esophageal Neoplasms Fermentation Fundamental and applied biological sciences. Psychology General aspects Humans Lactones - chemistry Lactones - isolation & purification Lactones - metabolism Lactones - pharmacology Macrolides Medical sciences Melanoma, Experimental Mice Microbiology migrastatin Neoplasms - pathology Pharmacology. Drug treatments Piperidones - chemistry Piperidones - isolation & purification Piperidones - metabolism Piperidones - pharmacology Protein Biosynthesis RNA - biosynthesis Streptomyces Streptomyces - classification Streptomyces - growth & development Streptomyces - metabolism Tumor Cells, Cultured Wound Healing - drug effects
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Beschreibung
Zusammenfassung:	A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC 17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.1130