Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities

The fruits of Neoraptua magnifica var. magnifica afforded three new flavonoids: 2′-hydroxy-4,4′,-dimethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, 2′-hydroxy-3,4,4′-trimethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, and 3′,4′-methylenedioxy-5,7-dimethoxyflavone which were identified on the basis of spectroscopic methods. The known flavonoids 2′-hydroxy-3,4,4′,5-tetramethoxy-5′,6′-(2″,2″-dimethylpyrano)chalcone, 2′-hydroxy-3,4,4′,5,6′-pentamethoxychalcone, 3′,4′-methylenedioxy-5,6,7-trimethoxyflavone, 3′,4′-methylenedioxy-5′,5,6,7-tetramethoxyflavone, 3′,4′,5′,5,7-pentamethoxyflavanone and 3′,4′,5′,5,7-pentamethoxyflavone were also identified. The latter flavone was the most active as glyceraldehyde-3-phosphate dehydrogenase-inhibitor