Decline in the HIV-1 Isolation Rate in Japan: A 12-Year Observation

Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total sample=2, 785) in Japan. During the past 12 years, we have found a decline in the HIY-1 isolation rate in Japan, with two identifiable turning points, 1991-1992 and 1996-1997. The two turning points correspond to shifts in ant...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 2000, Vol.44(11), pp.949-952
Hauptverfasser:	Nakasone, Tadashi, Takamatsu, Junki, Watanabe, Kuhomi, Naganawa, Satoshi, Someya, Kenji, Yoshino, Naoto, Kaizu, Masahiko, Ohsu, Takeaki, Takizawa, Mari, Izumi, Yasuyuki, Kawahara, Mamoru, Hara, Takashi, Fujimura, Yoshihiro, Yamada, Kaneo, Nagai, Yoshiyuki, Yamazaki, Shudo, Honda, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anti-HIV Agents - therapeutic use Biological and medical sciences Child Child, Preschool Drug Resistance, Microbial Epidemiology Female Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - virology HIV-1 HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus 1 Humans Infant Japan Japan - epidemiology Leukocytes, Mononuclear - virology Male Microbiology Middle Aged Viremia Virology Virus isolation
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Zusammenfassung:	Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total sample=2, 785) in Japan. During the past 12 years, we have found a decline in the HIY-1 isolation rate in Japan, with two identifiable turning points, 1991-1992 and 1996-1997. The two turning points correspond to shifts in anti-HIV-1 therapy. These findings suggest that HIV-1 in Japan is currently biologically well controlled, probably due to anti-HIV-1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic drug-resistant HIV-1 in Japan. Further studies are needed to clarify mechanisms that might explain the discrepancy.
ISSN:	0385-5600 1348-0421
DOI:	10.1111/j.1348-0421.2000.tb02588.x