Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1 H)-ones: A new class of GABA A brain receptor ligands

A novel class of potent benzodiazepine receptor (BZR) ligands has been designed and synthesized aided by molecular modeling of known benzodiazepine ligands such as CGS-8216 and the use of known pharmacophore models.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (24), p.2723-2726
Hauptverfasser:	DeSimone, Robert W., Blum, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzimidazoles - chemical synthesis Benzimidazoles - metabolism Benzodiazepines - chemical synthesis Benzodiazepines - metabolism Brain Chemistry GABA Agonists - chemical synthesis GABA Agonists - metabolism GABA Antagonists - chemical synthesis GABA Antagonists - metabolism Humans Ligands Models, Molecular Oxazoles - chemical synthesis Oxazoles - metabolism Protein Binding Pyrazoles - metabolism Receptors, GABA-A - metabolism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A novel class of potent benzodiazepine receptor (BZR) ligands has been designed and synthesized aided by molecular modeling of known benzodiazepine ligands such as CGS-8216 and the use of known pharmacophore models.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00550-3