Cephalosporin Podand Derivatives

In recent years the design and preparation of dendrimers and another multivalent molecules have emerged intensively studied subjects in organic synthesis. Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many cases, related multivalent compounds possess remarkable biological effects. As an example, the so-called cluster effect in the case of the carbohydrate-containing substances is manifested in the enhanced affinity of the dendrimers towards another biomolecules due to weak, non-bonding interactions. In the field of antibiotics, covalent oligomers or polymers have only been synthesized from vancomycin, and the complex-forming, and antibacterial properties of the derivatives obtained were found to be better than that of the parent, monomeric antibiotic.