Adenovirus vectors for gene expression

Adenovirus vectors for gene expression

Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal...

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Veröffentlicht in:Current opinion in biotechnology 1991-10, Vol.2 (5), p.718-722
Hauptverfasser: Chengalvala, Murty V.R., Lubeck, Michael D., Selling, Bernard J., Natuk, Robert J., Hsu, Kuo-Hom L., Mason, Bruce B., Chanda, Pranab K., Bhat, Ramesh A., Bhat, Bheem M., Mizutani, Satoshi, Davis, Alan R., Hung, Paul P.
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviridae - genetics
Animals
Biotechnology
Cloning, Molecular - methods
Gene Expression
Genetic Therapy
Genetic Vectors
Humans
Vaccines, Synthetic
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Beschreibung
Zusammenfassung:Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal models to exhibit excellent promise as vaccine candidates.
ISSN:0958-1669
1879-0429
DOI:10.1016/0958-1669(91)90041-3