Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl- d-aspartate receptor complex

As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl- d-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmac...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (23), p.2621-2623
Hauptverfasser:	Bence, Aimee K, Rogers, Dennis T, Worthen, David R, Fu, May, Littleton, John M, Crooks, Peter A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Anthraquinones - metabolism Binding Sites Biogenic Polyamines Biological and medical sciences Dizocilpine Maleate - metabolism Excitatory Amino Acid Antagonists - metabolism Glutamatergic system (aspartate and other excitatory aminoacids) Ligands Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Receptors, N-Methyl-D-Aspartate - metabolism
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Zusammenfassung:	As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl- d-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00530-8