A comparison of the frequency of stress ulceration and secondary pneumonia in sucralfate- or ranitidine-treated intensive care unit patients

OBJECTIVETo compare the frequency of acute stress ulceration and secondary pneumonia caused by aerobic Gram-negative bacilli in ICU patients treated with either sucralfate or ranitidine. DESIGNProspective, randomized study. SETTINGICU, university hospital. PATIENTSSixty adult patients who were mecha...

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Veröffentlicht in:	Critical care medicine 1991-12, Vol.19 (12), p.1491-1496
Hauptverfasser:	EDDLESTON, JANE M, VOHRA, AKBAR, SCOTT, PATRICK, TOOTH, J ANTHONY, PEARSON, ROBERT C, MCCLOY, RORY F, MORTON, ALAN K, DORAN, BARRY H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Bacteria, Aerobic Biological and medical sciences Critical Illness Digestive system Endoscopy, Gastrointestinal Female Gastric Acidity Determination Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - etiology Gram-Negative Bacterial Infections - microbiology Humans Infusions, Intravenous Male Medical sciences Middle Aged Peptic Ulcer - diagnosis Peptic Ulcer - drug therapy Peptic Ulcer - epidemiology Pharmacology. Drug treatments Pneumonia - epidemiology Pneumonia - etiology Pneumonia - microbiology Prospective Studies Ranitidine - administration & dosage Ranitidine - therapeutic use Respiration, Artificial - adverse effects Severity of Illness Index Stress, Physiological Sucralfate - administration & dosage Sucralfate - therapeutic use
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Zusammenfassung:	OBJECTIVETo compare the frequency of acute stress ulceration and secondary pneumonia caused by aerobic Gram-negative bacilli in ICU patients treated with either sucralfate or ranitidine. DESIGNProspective, randomized study. SETTINGICU, university hospital. PATIENTSSixty adult patients who were mechanically ventilated and at risk of developing stress ulceration. INTERVENTIONThe patients were randomized to receive either sucralfate (1 g every 6 hrs) via the nasogastric tube or iv ranitidine (50 mg every 6 hrs). If the gastric pH was
ISSN:	0090-3493 1530-0293
DOI:	10.1097/00003246-199112000-00009