Flutamide in the treatment of hirsutism
Ten hirsute women were treated with flutamide (250 mg/day) for 6 months to evaluate its effect. Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstened...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 1991-10, Vol.36 (2), p.155-157 |
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| container_issue | 2 |
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| container_title | International journal of gynecology and obstetrics |
| container_volume | 36 |
| creator | Motta, T. Maggi, G. Perra, M. Azzolari, E. Casazza, S. D'Alberton, A. |
| description | Ten hirsute women were treated with flutamide (250 mg/day) for 6 months to evaluate its effect. Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstenedione (P < 0.01). Acne and seborrhea improved markedly. No side effects were noted during the treatment. Our data suggest that the antiandrogenic properties of flutamide render it a suitable single agent in the treatment of hirsutism. |
| doi_str_mv | 10.1016/0020-7292(91)90772-W |
| format | Article |
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Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstenedione (P < 0.01). Acne and seborrhea improved markedly. No side effects were noted during the treatment. Our data suggest that the antiandrogenic properties of flutamide render it a suitable single agent in the treatment of hirsutism.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/0020-7292(91)90772-W</identifier><identifier>PMID: 1683319</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acne ; Adolescent ; Adult ; Biological and medical sciences ; Female ; Flutamide ; Flutamide - therapeutic use ; Hair growth ; Hirsutism ; Hirsutism - drug therapy ; Hormones ; Hormones. Endocrine system ; Humans ; Medical sciences ; Pharmacology. 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Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstenedione (P < 0.01). Acne and seborrhea improved markedly. No side effects were noted during the treatment. Our data suggest that the antiandrogenic properties of flutamide render it a suitable single agent in the treatment of hirsutism.</description><subject>Acne</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Flutamide</subject><subject>Flutamide - therapeutic use</subject><subject>Hair growth</subject><subject>Hirsutism</subject><subject>Hirsutism - drug therapy</subject><subject>Hormones</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Seborrhea</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1LxDAQxYMo67r6Hyj0IH4cqpmmTZqLIKKrInhR9hjSZMpG-qFJq_jf27WL3sTTHOb33sx7hOwDPQMK_JzShMYikcmJhFNJhUjixQaZQi5kzFIhN8n0B9kmOyG8UEpBAEzIBHjOGMgpOb6p-k7XzmLkmqhbYtR51F2NTRe1ZbR0PvSdC_Uu2Sp1FXBvPWfk-eb66eo2fnic311dPsQmZTyLM2aKIs8olVYIIzgFazPGRGpZiYlOS8OBJtZSLnkhE8ZonlueWciRQZFyNiNHo--rb996DJ2qXTBYVbrBtg9KJKkUbHh-RtIRNL4NwWOpXr2rtf9UQNWqH7UKr1bhlQT13Y9aDLKDtX9f1Gh_RWMhw_5wvdfB6Kr0ujEu_GCrZBzyAZMj9uEq_PzXaXV3P3-ELBu0F6MWhx7fHXoVjMPGoHUeTads6_7O8AXj5I-X</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Motta, T.</creator><creator>Maggi, G.</creator><creator>Perra, M.</creator><creator>Azzolari, E.</creator><creator>Casazza, S.</creator><creator>D'Alberton, A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199110</creationdate><title>Flutamide in the treatment of hirsutism</title><author>Motta, T. ; Maggi, G. ; Perra, M. ; Azzolari, E. ; Casazza, S. ; D'Alberton, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-53cbb85009d77c7601dd53374d3fe2a4fc6102dd0696b9233088d65d18e31b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acne</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Flutamide</topic><topic>Flutamide - therapeutic use</topic><topic>Hair growth</topic><topic>Hirsutism</topic><topic>Hirsutism - drug therapy</topic><topic>Hormones</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Seborrhea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motta, T.</creatorcontrib><creatorcontrib>Maggi, G.</creatorcontrib><creatorcontrib>Perra, M.</creatorcontrib><creatorcontrib>Azzolari, E.</creatorcontrib><creatorcontrib>Casazza, S.</creatorcontrib><creatorcontrib>D'Alberton, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motta, T.</au><au>Maggi, G.</au><au>Perra, M.</au><au>Azzolari, E.</au><au>Casazza, S.</au><au>D'Alberton, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flutamide in the treatment of hirsutism</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>1991-10</date><risdate>1991</risdate><volume>36</volume><issue>2</issue><spage>155</spage><epage>157</epage><pages>155-157</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Ten hirsute women were treated with flutamide (250 mg/day) for 6 months to evaluate its effect. Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstenedione (P < 0.01). Acne and seborrhea improved markedly. No side effects were noted during the treatment. Our data suggest that the antiandrogenic properties of flutamide render it a suitable single agent in the treatment of hirsutism.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1683319</pmid><doi>10.1016/0020-7292(91)90772-W</doi><tpages>3</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 1991-10, Vol.36 (2), p.155-157 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Wiley Online Library Journals Frontfile Complete |
| subjects | Acne Adolescent Adult Biological and medical sciences Female Flutamide Flutamide - therapeutic use Hair growth Hirsutism Hirsutism - drug therapy Hormones Hormones. Endocrine system Humans Medical sciences Pharmacology. Drug treatments Seborrhea |
| title | Flutamide in the treatment of hirsutism |
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