Flutamide in the treatment of hirsutism

Flutamide in the treatment of hirsutism

Ten hirsute women were treated with flutamide (250 mg/day) for 6 months to evaluate its effect. Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstened...

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Veröffentlicht in:International journal of gynecology and obstetrics 1991-10, Vol.36 (2), p.155-157
Hauptverfasser: Motta, T., Maggi, G., Perra, M., Azzolari, E., Casazza, S., D'Alberton, A.
Format: Artikel
Sprache:eng
Schlagworte:
Acne
Adolescent
Adult
Biological and medical sciences
Female
Flutamide
Flutamide - therapeutic use
Hair growth
Hirsutism
Hirsutism - drug therapy
Hormones
Hormones. Endocrine system
Humans
Medical sciences
Pharmacology. Drug treatments
Seborrhea
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Zusammenfassung:Ten hirsute women were treated with flutamide (250 mg/day) for 6 months to evaluate its effect. Hair growth as assessed by the Ferriman and Gallwey hair score was significantly reduced in all patients (P < 0.01). The only significant change in endocrine levels was an increase in serum androstenedione (P < 0.01). Acne and seborrhea improved markedly. No side effects were noted during the treatment. Our data suggest that the antiandrogenic properties of flutamide render it a suitable single agent in the treatment of hirsutism.
ISSN:0020-7292
1879-3479
DOI:10.1016/0020-7292(91)90772-W