The Effect of a Standard Oral Calcium Load Given in Two Different Forms on Plasma Ionized Calcium and Serum PTH

A standard dose (1 g, 25 · 4 mmol) of calcium was administered both as calcium chloride in syrup and as Calcium-Sandoz Syrup (calcium glubionate and calcium galactogluconate) to 10 volunteers. Both dosage forms caused a significant rise in ionized calcium and a significant fall in concentration of s...

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Veröffentlicht in:	Annals of clinical biochemistry 1991-09, Vol.28 (5), p.446-449
1. Verfasser:	Bailey, Ian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Biological and medical sciences Calcium - administration & dosage Calcium - pharmacokinetics Calcium Chloride - administration & dosage Calcium Chloride - pharmacokinetics Calcium Gluconate - administration & dosage Calcium Gluconate - pharmacokinetics Dosage Forms Fundamental and applied biological sciences. Psychology Humans Hydrogen-Ion Concentration Hypercalcemia - blood Hyperparathyroidism - blood Organometallic Compounds - administration & dosage Organometallic Compounds - pharmacokinetics Parathyroid Hormone - blood Trisaccharides - administration & dosage Trisaccharides - pharmacokinetics Vertebrates: urinary system
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Beschreibung
Zusammenfassung:	A standard dose (1 g, 25 · 4 mmol) of calcium was administered both as calcium chloride in syrup and as Calcium-Sandoz Syrup (calcium glubionate and calcium galactogluconate) to 10 volunteers. Both dosage forms caused a significant rise in ionized calcium and a significant fall in concentration of serum PTH, the calcium chloride producing significantly greater changes. The urinary excretion of calcium measured over 5 h after calcium chloride was double that after Calcium-Sandoz. Calcium chloride, as expected, also gave rise to a decreased urine pH. Calcium chloride would be the better choice for an oral PTH suppression test.
ISSN:	0004-5632 1758-1001
DOI:	10.1177/000456329102800504