Metal-binding sites in proteins

Metal-binding sites in proteins

A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now...

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Veröffentlicht in:Current opinion in biotechnology 1991-08, Vol.2 (4), p.582-591
Hauptverfasser: Tainer, John A., Roberts, Victoria A., Getzoff, Elizabeth D.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Binding Sites
Biotechnology
Metalloproteins - chemistry
Metals - chemistry
Models, Molecular
Molecular Sequence Data
Protein Engineering
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Zusammenfassung:A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.
ISSN:0958-1669
1879-0429
DOI:10.1016/0958-1669(91)90084-I