Increased Blood Flow Inhibits Neointimal Hyperplasia in Endothelialized Vascular Grafts

Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased blood flow on intimal hyperplasia in porous polytetrafluoroethylene grafts implanted in baboons. These grafts develop an endothelial lining by 2...

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Veröffentlicht in:	Circulation research 1991-12, Vol.69 (6), p.1557-1565
Hauptverfasser:	Kohler, Ted R, Kirkman, Thomas R, Kraiss, Larry W, Zierler, Brenda K, Clowes, Alexander W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Flow Velocity Blood Vessel Prosthesis Endothelium, Vascular - pathology Hemodynamics Hyperplasia Male Medical sciences Muscle, Smooth, Vascular - pathology Papio Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular Patency Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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Beschreibung
Zusammenfassung:	Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased blood flow on intimal hyperplasia in porous polytetrafluoroethylene grafts implanted in baboons. These grafts develop an endothelial lining by 2 weeks and neointimal thickening due to proliferation of underlying smooth muscle cells by 1 month. Creation of a distal arteriovenous fistula increased flow (from 230±35 to 785±101 ml/min, p
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.res.69.6.1557