AgNOR area in interphase nuclei of human tumours correlates with the proliferative activity evaluated by bromodeoxyuridine labelling and Ki-67 immunostaining

The area of silver‐stained proteins associated with interphase nucleolar organizer regions (AgNORs) was compared with labelling data obtained by bromodeoxyuridine (BrdU) incorporation and Ki‐67 immunostaining in 25 tumours of different origins and two non‐neoplastic lesions of the thyroid. Our data...

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Veröffentlicht in:The Journal of pathology 1991-09, Vol.165 (1), p.53-59
Hauptverfasser: Trerè, Davide, Farabegoli, Fulvia, Cancellieri, Alessandra, Ceccarelli, Claudio, Eusebi, Vincenzo, Derenzini, Massimo
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Sprache:eng
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Zusammenfassung:The area of silver‐stained proteins associated with interphase nucleolar organizer regions (AgNORs) was compared with labelling data obtained by bromodeoxyuridine (BrdU) incorporation and Ki‐67 immunostaining in 25 tumours of different origins and two non‐neoplastic lesions of the thyroid. Our data demonstrate a highly significant correlation between the mean area occupied by the AgNOR proteins masured by an image processing system and the proliferative indices evaluated by BrdU labelling (r = 0·89, P < 0·001) and Ki‐67 immunostaining (r = 0·86, P < 0·001). AgNOR protein area measurement is therefore proposed as a simple, inexpensive, and reliable method of evaluating the proliferative activity in routinely processed tumour samples.
ISSN:0022-3417
1096-9896
DOI:10.1002/path.1711650109