Circulating thrombomodulin in thrombotic thrombocytopenic purpura

Endothelial cell injury is thought to be one of the causative factors in thrombotic thrombocytopenic purpura (TTP). A novel index of endothelial injury, plasma thrombomodulin, was measured in 13 patients with acute TTP. The mean plasma concentration of thrombomodulin was elevated in patients with TT...

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Veröffentlicht in:	American journal of hematology 1991-11, Vol.38 (3), p.174-177
Hauptverfasser:	Takahashi, Hoyu, Hanano, Masaharu, Wada, Ken, Tatewaki, Wataru, Niwano, Hiroe, Shibata, Akira, Tsubouchi, Jiro, Nakano, Masahiko, Nakamura, Tadao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences endothelial cell injury Female Fibrin Fibrinogen Degradation Products - analysis Hematologic and hematopoietic diseases Humans Lupus Erythematosus, Systemic - blood Male Medical sciences Middle Aged Osmolar Concentration Purpura, Thrombotic Thrombocytopenic - blood Purpura, Thrombotic Thrombocytopenic - therapy Receptors, Cell Surface - metabolism Receptors, Thrombin Reference Values Remission Induction Thrombin - metabolism tissue‐type plasminogen activator vascular injury von Willebrand factor von Willebrand Factor - analysis
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Zusammenfassung:	Endothelial cell injury is thought to be one of the causative factors in thrombotic thrombocytopenic purpura (TTP). A novel index of endothelial injury, plasma thrombomodulin, was measured in 13 patients with acute TTP. The mean plasma concentration of thrombomodulin was elevated in patients with TTP (34.23 ± 19.08 ng/ml) as compared with healthy subjects (16.99 ± 2.63 ng/ml, P
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830380304