New Cytotoxic Sesquiterpenes from the Gorgonian Isis hippuris

Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-12, Vol.63 (12), p.1603-1607
Hauptverfasser:	Sheu, Jyh-Horng, Hung, Kuang-Chih, Wang, Guey-Horng, Duh, Chang-Yih
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Cnidaria - chemistry Drug Screening Assays, Antitumor General pharmacology Gorgonacea Humans Isis hippuris Marine Medical sciences Molecular Structure natural products Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sesquiterpenes Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spectrum Analysis subergorgic acid suberosanone suberosenol A suberosenol A acetate suberosenol B suberosenol B acetate Tumor Cells, Cultured
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Zusammenfassung:	Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3−5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000271n