Distribution of ApoA-I–Containing HDL Subpopulations in Patients With Coronary Heart Disease

Abstract—High density lipoproteins (HDLs) and their subspecies play a role in the development of coronary heart disease (CHD). HDL subpopulations were measured by 2-dimensional nondenaturing gel electrophoresis in 79 male control subjects and 76 male CHD patients to test the hypothesis that greater...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2000-12, Vol.20 (12), p.2670-2676
Hauptverfasser:	Asztalos, Bela F, Roheim, Paul S, Milani, Richard L, Lefevre, Michael, McNamara, Judith R, Horvath, Katalin V, Schaefer, Ernst J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis of Variance Apolipoprotein A-I - chemistry Apolipoprotein A-I - metabolism Biological and medical sciences Cardiology. Vascular system Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary Disease - blood Coronary Disease - metabolism Coronary heart disease Electrophoresis, Gel, Two-Dimensional Heart Humans Lipoproteins, HDL - chemistry Lipoproteins, HDL - metabolism Male Medical sciences Middle Aged Risk Factors
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Zusammenfassung:	Abstract—High density lipoproteins (HDLs) and their subspecies play a role in the development of coronary heart disease (CHD). HDL subpopulations were measured by 2-dimensional nondenaturing gel electrophoresis in 79 male control subjects and 76 male CHD patients to test the hypothesis that greater differences in apolipoprotein (apo)A-I–containing HDL subpopulations would exist between these 2 groups than for traditional lipid levels. In CHD subjects, HDL cholesterol (HDL-C) was lower (−14%, P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.ATV.20.12.2670