AB(5) toxins: structures and inhibitor design

AB(5) toxins: structures and inhibitor design

High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent li...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in structural biology 2000-12, Vol.10 (6), p.680-686
Hauptverfasser: Fan, E, Merritt, E A, Verlinde, C L, Hol, W G
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial Toxins - antagonists & inhibitors
Bacterial Toxins - chemistry
Bacterial Toxins - metabolism
Drug Design
Membrane Proteins - metabolism
Protein Conformation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their receptors.
ISSN:0959-440X
DOI:10.1016/S0959-440X(00)00152-4