Relationship between Sulfate Groups and Biological Activities of Fucans

The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line. The resul...

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Veröffentlicht in:	Thrombosis research 2000-12, Vol.100 (5), p.453-459
Hauptverfasser:	Haroun-Bouhedja, Ferial, Ellouali, Mostafa, Sinquin, Corinne, Boisson-Vidal, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulant activity Anticoagulants - chemistry Anticoagulants - metabolism Anticoagulants - pharmacology Antiproliferative activity Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cell Line Fucans Fucose Medical sciences Pharmacology. Drug treatments Polysaccharides - chemistry Polysaccharides - metabolism Polysaccharides - pharmacology Seaweed Structure-Activity Relationship Sulfate content dependence Sulfates
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Zusammenfassung:	The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line. The results showed that inhibitory effects of fucans on both coagulation and cell proliferation are dependent on their sulfation degree. Decreased sulfation diminishes the two activities not in the same manner: some low molecular weight fucan fractions with no anticoagulant activity retain their ability to inhibit cell growth.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/S0049-3848(00)00338-8