Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats

The Wistar fatty (WF) rat is a model of obese Type 2 diabetes mellitus (DM). These rats were bred by crossing Zucker fatty (ZF) and Wistar–Kyoto (WKY) rats. A homo-allelic leptin receptor gene mutation has been reported in ZF rats. We report here how these genetic factors contribute to plasma insuli...

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Veröffentlicht in:	Physiology & behavior 2000-09, Vol.70 (5), p.527-532
Hauptverfasser:	Ohnuma, H, Yamatani, K, Daimon, M, Igarashi, M, Manaka, H, Sasaki, H, Kato, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine Derivatives - administration & dosage Behavioral psychophysiology Biological and medical sciences Blood Glucose Carrier Proteins - genetics Carrier Proteins - metabolism Crosses, Genetic Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Fundamental and applied biological sciences. Psychology Glucagon - blood Glucagon-Like Peptide 1 Glucose Tolerance Test Hepatic vagotomy Hormones and behavior Injections, Intraventricular Insulin Insulin - blood Insulin - metabolism Insulin Resistance - genetics Insulin Secretion Leptin receptor gene mutation Mutation Obesity Peptide Fragments - blood Protein Precursors - blood Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred WKY Rats, Zucker Receptors, Cell Surface Receptors, Leptin Vagotomy Vagus Nerve - physiopathology Vagus Nerve - surgery Wistar fatty rat Zucker fatty rat
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Zusammenfassung:	The Wistar fatty (WF) rat is a model of obese Type 2 diabetes mellitus (DM). These rats were bred by crossing Zucker fatty (ZF) and Wistar–Kyoto (WKY) rats. A homo-allelic leptin receptor gene mutation has been reported in ZF rats. We report here how these genetic factors contribute to plasma insulin regulation. The fasting plasma insulin levels were higher in WKY and Wistar lean (WL) rats than in Zucker lean (ZL) rats ( p
ISSN:	0031-9384 1873-507X
DOI:	10.1016/S0031-9384(00)00297-3