Electrophysiological deterioration during long-duration ventricular fibrillation

Probability of survival from sudden cardiac arrest caused by ventricular fibrillation (VF) decreases rapidly with fibrillation duration. We hypothesized that cellular ischemia/fibrillation-induced electrophysiological deterioration underlies decreased survival. We determined fibrillation monophasic...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-12, Vol.102 (23), p.2886-2891
Hauptverfasser:	TOVAR, Oscar H, JONES, Janice L
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Disease Models, Animal Electrocardiography - statistics & numerical data Heart Heart - physiopathology Heart Arrest - mortality Heart Arrest - physiopathology Heart Arrest - therapy Medical sciences Rabbits Resuscitation Survival Analysis Ventricular Fibrillation - diagnosis Ventricular Fibrillation - physiopathology Ventricular Fibrillation - therapy
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Zusammenfassung:	Probability of survival from sudden cardiac arrest caused by ventricular fibrillation (VF) decreases rapidly with fibrillation duration. We hypothesized that cellular ischemia/fibrillation-induced electrophysiological deterioration underlies decreased survival. We determined fibrillation monophasic action potential (MAP) morphology including action potential frequency content, duration, cycle length, developing diastolic intervals, and amplitude as a function of ischemic fibrillation duration in 10 isolated rabbit hearts. We also correlated ECG frequency (used clinically) and MAP amplitude and frequency. Fibrillation cycle length and diastole duration increased, whereas APD(100) shortened significantly with time (P:
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.102.23.2886