Ventricular Fibrillation: How Do We Stop the Waves From Breaking?

ABSTRACT—Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably...

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Veröffentlicht in:	Circulation research 2000-12, Vol.87 (12), p.1103-1107
Hauptverfasser:	Weiss, James N, Chen, Peng-Sheng, Qu, Zhilin, Karagueuzian, Hrayr S, Garfinkel, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Anti-Arrhythmia Agents - therapeutic use Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - etiology Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Electrophysiology Heart History, Modern 1601 Humans Medical sciences Ventricular Fibrillation - physiopathology Ventricular Fibrillation - prevention & control
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Zusammenfassung:	ABSTRACT—Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.87.12.1103