Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization

Originally identified in Epstein-Barr virus transformed B cells where it binds to EBNA-2 (a transcription factor encoded by EBV), the coactivator p100 also binds to the RNA polymerase II initiation factor TFIIE and also interacts with the oncoproteins c-myb and v-myb (Tong et al., 1995; Dash et al., 1996; Leverson et al., 1998). These and other results suggest that p100 and its rat homologue p105 play a role in the regulation of cell proliferation and in cellular transformation. In this study we assigned the gene encoding the coactivator p100 (symbol: SND1, staphylococcal nuclease domain containing 1) to human chromosome band 7q31.3 and its rat homolog (Snd1) to rat chromosome band 4q23.