ISOLATION OF A BROMO ANALOG OF REBECCAMYCIN FROM Saccharothrix aerocolonigenes

When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography....

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Veröffentlicht in:	Journal of antibiotics 1991/09/25, Vol.44(9), pp.934-939
Hauptverfasser:	LAM, KIN SING, SCHROEDER, DANIEL R., VEITCH, JACQUELINE M., MATSON, JAMES A., FORENZA, SALVATORE
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - therapeutic use Antineoplastic agents Biological and medical sciences Carbazoles Chemical Phenomena Chemistry Chromatography, High Pressure Liquid General aspects Indoles Leukemia P388 - drug therapy Medical sciences Mice Pharmacology. Drug treatments Saccharomycetales - chemistry
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Beschreibung
Zusammenfassung:	When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography. Spectroscopic data demonstrated that bromorebeccamycin has the same structure as rebeccamycin, except for the replacement of the two chlorine atoms by bromine atoms in the molecule. Bromorebeccamycin and rebeccamycin have a similar potency and activity against P388 leukemia in the murine model.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.44.934