Response of brain protein kinase C isozymes to ethyl oleate, an alcohol metabolite

Rat brain protein kinase C (PKC) isozymes I, II and III were stimulated by fatty acids in the absence and presence of calcium. Ethyl oleate, which by itself has no effect on PKC activity, had a potentiating effect on fatty acid-induced activation of all 3 isozymes. Potentiation was observed predomin...

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Veröffentlicht in:	Brain research 1991-08, Vol.558 (1), p.98-100
Hauptverfasser:	Holian, Oksana, Ruiz, Cathy, Kumar, Raj, Nyhus, Lloyd M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Arachidonic Acid - pharmacology Biological and medical sciences Brain - enzymology Calcium - pharmacology Diglycerides - chemistry Diglycerides - pharmacology Ethanol Ethyl oleate Fatty acid Fatty Acids - pharmacology Isoenzymes - metabolism Medical sciences Oleic Acids - metabolism Protein Kinase C - metabolism Protein kinase C activation Protein kinase C isozyme Rats Signal transduction Structure-Activity Relationship Toxicology
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Beschreibung
Zusammenfassung:	Rat brain protein kinase C (PKC) isozymes I, II and III were stimulated by fatty acids in the absence and presence of calcium. Ethyl oleate, which by itself has no effect on PKC activity, had a potentiating effect on fatty acid-induced activation of all 3 isozymes. Potentiation was observed predominantly in the presence of calcium. Interaction of ethyl oleate with a signalling mechanism involving PKC may underlie the cognitive disturbances noted after alcohol consumption.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(91)90720-G