Predictive Value of the Fluorescent Cytoprint Assay (FCA): A Retrospective Correlation Study of In Vitro Chemosensitivity and Individual Responses to Chemotherapy

Predictive Value of the Fluorescent Cytoprint Assay (FCA): A Retrospective Correlation Study of In Vitro Chemosensitivity and Individual Responses to Chemotherapy

Abstract The potential clinical usefulness of the fluorescent cytoprint assay (FCA) was assessed retrospectively in 73 cancer patients by correlating individual tumor chemosensitivity in vitro with responses to chemotherapy. The data show that the FCA has a sensitivity of 98%, specificity of 81%, an...

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Veröffentlicht in:Cancer investigation 1991, Vol.9 (5), p.491-503
Hauptverfasser: Leone, Louis A., Meitner, Patricia A., Myers, Thomas J., Grace, William R., Gajewski, Walter H., Fingert, Howard J., Rotman, Boris
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - therapeutic use
Drug Screening Assays, Antitumor - methods
Female
Fluorescence
Humans
In Vitro Techniques
Male
Neoplasms - drug therapy
Predictive Value of Tests
Remission Induction
Retrospective Studies
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Zusammenfassung:Abstract The potential clinical usefulness of the fluorescent cytoprint assay (FCA) was assessed retrospectively in 73 cancer patients by correlating individual tumor chemosensitivity in vitro with responses to chemotherapy. The data show that the FCA has a sensitivity of 98%, specificity of 81%, and predictive accuracies of 85% and 97% for positive and negative clinical responses, respectively.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357909109018947