Medullipin System Generation of Medullipin II by Isolated Kidney-Liver Perfusion

Perfusion of isolated normal rat kidneys with blood at elevated blood pressure (180–200 mm Hg) followed by perfusion of the renal perfusate through an isolated normal rat liver under venous pressure yielded in the plasma of the hepatic effluent a vasodepressor lipid having the chromatographic and bi...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-11, Vol.18 (5 Suppl III), p.III-158-III-163
Hauptverfasser:	Muirhead, E Eric, Brooks, Bennie, Byers, Lawrence W, Brown, Peggy, Pitcock, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - metabolism Biological and medical sciences Blood Pressure Endocrine kidney. Renin-angiotensin-aldosterone system Fundamental and applied biological sciences. Psychology In Vitro Techniques Kidney Medulla - metabolism Lipids - biosynthesis Liver - metabolism Male Perfusion Rats Rats, Inbred Strains Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	Perfusion of isolated normal rat kidneys with blood at elevated blood pressure (180–200 mm Hg) followed by perfusion of the renal perfusate through an isolated normal rat liver under venous pressure yielded in the plasma of the hepatic effluent a vasodepressor lipid having the chromatographic and biological characteristics of medullipin II. These findings support the view that medullipin II is the final product of the renohepatic axis of blood pressure control.
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.hyp.18.5_suppl.iii158