Cholesterol esters and atherosclerosis-a game of ACAT and mouse

Disruption of the gene encoding the cholesterol modifying enzyme ACAT2 in mice leads to a reduced capacity to absorb cholesterol and resistance to diet-induced hypercholesterolemia. This suggests that ACAT2 may be a good target for prevention of atherosclerosis. ( pages 1341–1347 )

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2000-12, Vol.6 (12), p.1313-1314
Hauptverfasser:	Rudel, Lawrence L, Shelness, Gregory S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - etiology Atherosclerosis Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Cholesterol Esters - metabolism Cholesterol metabolism Cholesterol, Dietary - metabolism choline acetyltransferase Esters Genetic aspects Hypercholesterolemia - genetics Infectious Diseases Intestinal Absorption - genetics Metabolic Diseases Mice Mice, Mutant Strains Models, Biological Molecular Medicine Neurosciences news-and-views Physiological aspects Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase - metabolism Transferases
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Beschreibung
Zusammenfassung:	Disruption of the gene encoding the cholesterol modifying enzyme ACAT2 in mice leads to a reduced capacity to absorb cholesterol and resistance to diet-induced hypercholesterolemia. This suggests that ACAT2 may be a good target for prevention of atherosclerosis. ( pages 1341–1347 )
ISSN:	1078-8956 1546-170X
DOI:	10.1038/82110