Latent Mycobacterium tuberculosis -persistence, patience, and winning by waiting

Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated....

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Veröffentlicht in:	Nature medicine 2000-12, Vol.6 (12), p.1327-1329
Hauptverfasser:	Manabe, Yukari C, Bishai, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acquired Immunodeficiency Syndrome - complications Adaptation, Biological Animals Antimicrobial agents Antitubercular agents Autopsies Bacteria Biomedical and Life Sciences Biomedicine Cancer Research Causes of Dosage and administration Drug therapy Genetic aspects Granulomas Health aspects HIV Human immunodeficiency virus Humans Immune system Infections Infectious Diseases Metabolic Diseases Mice Models, Biological Molecular Medicine Mycobacterium tuberculosis Mycobacterium tuberculosis - pathogenicity Neurosciences Pathogens Prevention review-article RNA polymerase Tuberculosis Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - immunology Vaccines
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Beschreibung
Zusammenfassung:	Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/82139